منابع مشابه
Selective gene amplification.
We describe a system for directed evolution based on in vitro compartmentalisation in which amplification of a gene is coupled to the formation of product by the enzyme it encodes. This approach mimics the process of natural selection; 'fitter' genes--encoding more efficient enzymes--have more 'offspring'. It allows selection for any activity so long as a product-specific ligand (e.g. an antibo...
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Gene amplification increases the number of genes in a genome and can give rise to karyotype abnormalities called double minutes (DM) and homogeneously staining regions (HSR), both of which have been widely observed in human tumors but are also known to play a major role during embryonic development due to the fact that they are responsible for the programmed increase of gene expression. The eti...
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INTRODUCTION ..................................................................................... 417 A Leishmania Primer ............................................................................ 418 The Leishmania Genome and Circular DNAs ............................................... 419 MULTIPLE MECHANISMS OF DRUG RESISTANCE ...................................... 420 GENES AMPLIFIED IN ...
متن کاملSpectral estimation via selective harmonic amplification
The state-covariance of a linear filter is characterized by a certain algebraic commutativity property with the state matrix of the filter, and also imposes a generalized interpolation constraint on the power spectrum of the input process. This algebraic property and the relationship between state-covariance and the power spectrum of the input allow the use of matrix pencils and analytic interp...
متن کاملSelective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme.
Primary brain tumors of glial origin often overexpress epidermal growth factor receptors (EGF-Rs). This may be associated with amplification of the EGF-R gene. We have examined tissue from 23 glioblastoma multiforme tumors and found amplification and rearrangement of the EGF-R gene in four of these. The cytoplasmic domain of the EGF-R gene was invariably amplified in these four tumors, while th...
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ژورنال
عنوان ژورنال: Protein Engineering Design and Selection
سال: 2007
ISSN: 1741-0126,1741-0134
DOI: 10.1093/protein/gzm060